A team led by researchers from Boston University School of Medicine has identified a gene that can be destroyed to halt the development of melanoma. This is the most famous and deadly form of skin cancer that affects many people. In fact, this is everyone who is forced to be under bright sunlight for a long time, the ultraviolet radiation of which damages the DNA in skin cells.
Early-stage melanoma is relatively successfully treated with immunotherapy and targeted therapies, but approximately 25% of cases are caused by mutations in the NRAS gene. And until recently, such cases baffled doctors. After many years of research, it became clear that it was impossible to deactivate the NRAS itself. And then the scientists set their sights on the proteins that "trigger" this gene.
The most likely candidate for the role of a trigger for NRAS is the protein with the STK19 index. It was known before, but scientists debated its function until they started looking for NRAS activators. Having identified the key protein, it was not difficult for them to neutralize it - the synthesized drug was successfully tested on skin samples grown in a laboratory, and then on experimental animals.
Now the matter is small, but the most important thing - you need to check the efficiency of the medicine in humans. Scientists have almost no doubts about the success, but they still find it difficult to answer the question about the side effects.