Scientists have long known that drug-containing nanoparticles targeting affected areas of the body can heal diseases such as cancer. However, this raises one serious problem: the immune system "revolts" against them and destroys them. A team of researchers from California undertook to solve the problem, which set the task of "disguising" the nanoparticles as fragments of blood cells.
As you know, most nanoparticles are made on the basis of metal or plastics. Therefore, it is not surprising that the body perceives them as foreign bodies and begins to fight them. To lull the body's "vigilance", scientists resorted to a trick, covering plastic nanoparticles containing an antibiotic with a substance with cell membranes extracted from human blood platelets.
Membranes contain a number of proteins that protect cells from immune attack. Experiments on the implantation of nanoparticles were carried out in mice infected with methicillin-resistant Staphylococcus aureus (MRSA), which causes a fatal infection in humans. In infected mice, after treatment with nanoparticles, a 1000-fold decrease in the number of bacteria in the spleen and liver was noted compared to their relatives who received conventional antibiotics.
Scientists intend to continue their experiments on larger animals before starting clinical trials in humans.